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By F. Ugolf. Siena College.

Cake eyeliner was popular in the past and was a wettable pressed cake applied with a wet brush purchase 5mg dulcolax mastercard medications migraine headaches. Pencils Pencils are used in general for coloring the eyebrows and eyelids dulcolax 5mg line symptoms prostate cancer, although they are now popular as lipsticks, lip liner, and blushers depending on the hardness of the pencil and the color composition. Chemists’ responsibility is to evaluate the finished product, rather than cre- ate one. Evaluation includes shade, texture, sharpenability, wear, application, sta- bility (freeze-thaw and at 40–45°C) and penetration. Lipsticks Lipsticks add color to the face for a healthier look, shape and sometimes condi- tions the lips. Ingredients in a Classical Lipstick Emollients: castor oil, esters, lanolin/lanolin oil, oily alcohols (octyl dode- canol), organically modified silicones (phenyltrimethicone and alkyl di- methicones), meadowfoam seed oil, jojoba oil and esters and triglycer- ides Waxes: candelilla, carnauba, beeswax and derivatives, microcrystalline, ozokerite/ceresein, alkyl silicone, castor, polyethylene, lanolin, paraffin, synthetic and ester Wax modifiers (plasticizers): work in conjunction with the waxes to im- prove texture, application and stability include cetyl acetate and ace- tylated lanolin, oleyl alcohol, synthetic lanolin, acetylated lanolin alcohol and petroleum (white and yellow) Colorants widely used—D&C’s (Red #6 and Ba Lake, Red #7 and Ca Lake, Red #21 and Al Lake- (stains), Red #27 and A1 Lake- (stains), 304 Schlossman Red #33 and Al Lake, Red #30, Red #36, Yellow #10). Grind phase is added to complete emollient phase and waxes, heated and mixed until uniform (approx. Pearls and fillers are added to above phases and mixed with shear (if necessary) until homogeneous. Maintain a temperature just above the initial set point of the waxes and fill as appropriate. Ingredients for Volatile Lipstick The proper balance of solvents and emollients prevent transfer and allow lipstick not to become too dry on the lips (15). They should be waterproof, glossy, adherent, dry quickly and be resistant to chipping and abrasion. The main constituents include a film former, modifying resin, plasti- cizer, and solvents. Additionally, pigments, suspending agents and ultraviolet absorbers are usually included. Nitrocellulose is derived from cellulose, a polymer made of several anhy- droglucose units connected by ether linkages. Nitrocellulose by itself will produce a hard brittle film so it is necessary to modify it with resins and plasti- cizers to provide flexibility and gloss. The most commonly used modifying resin is para foluene sulfonamide formaldehyde resin, which is contained at 5–10% levels. This resin provides gloss, adhesion, and increases the hardness of the nitrocellulose film. The formaldehyde resin has caused allergies with a small number of consumers so that other modifiers such as sucrose benzoate, polyester 306 Schlossman resin and toluene sulfonamide epoxy resin have been used in its place with varying results. Plasticizers used include camphor, glyceryl diesters (16), di- butyl phthalate, citrate esters and castor oil. Other resins such as polyurethanes and acrylics have been used as auxiliary resins. Variations of plasticizers and resins will change the viscosity, dry time, and gloss of the lacquer. Colorants include titanium dioxide, iron oxides, most organics, and pearlescent pigments. In order to reduce settling of the heavier pigments, treatment such as silicone (17) and oxidized polyethylene (18) have been utilized. Modified clays derived from bentonite and/or hectorite are used to suspend the pigments and make the nail enamel thixotropic and brushable. Solvents that constitute approximately 70% of nail lacquers include n-butyl acetate, ethyl acetate, and toluene. Cream shades may be shear or full coverage with titanium dioxide as the chief pigment. Pearlescent nail polish usually contains bismuth oxychloride and/or titanium dioxide coated micas and may even contain guanine-natural fish scales.

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Cortisol regulates blood sugar effective 5 mg dulcolax medicine nelly, immune function dulcolax 5mg low cost symptoms 1 week after conception, and blood pressure, plus it inhibits or stimulates many other hormones. When stress is excessive or perceived to be excessive, initially cortisol (a member of the glucocorticoid family) rises in the blood, saliva, and urine. High cortisol blocks or lowers the production of thyroid hormones, sex hormones (such as estrogen and progesterone), growth hormone, and melatonin. Over time, if the adrenals can no longer continue the high output, cortisol levels will decrease. I’ve included several hormonal formulas in this chapter to help you understand the interactions among the variables, which are hormones and actions that affect hormones, such as physiological stress. Here’s one applicable to adults to get us started: This simple equation shows that stress goes up when your adrenals are off kilter and make too much cortisol. Stress levels go down with restorative sleep, regular exercise, nutrient-dense food, and contemplative practice, such as meditation. Stress and Dysregulated Adrenals: Common Hormonal Combinations Referring back to the questionnaires in chapter 1, if you answered “yes” to three or more of the questions as in either Part A or Part B (or collectively, more than three in both Part A and Part B), plus three or more in another part, you have a problem with the cross talk between the adrenal glands and either the thyroid or the ovaries. Finally, you’ve got an explanation for the crushing fatigue, poor mood, lack of libido, and climbing weight—you’re not going crazy. You begin taking medication, usually a synthetic T4 such as Synthroid or levothyroxine as a tablet by mouth. There are many women who are properly prescribed thyroid hormone and do not experience the party-crashing adrenal on their thyroid honeymoon. But if your symptoms are atypical, or you feel better but then backslide, or if you answered “yes” to three or more questions in chapter 1, Part A and/or Part B and Part G, I suggest you take into account the important chain reaction between the thyroid and adrenal systems, because an adrenal problem will cause your thyroid issue to be much worse and harder to correct, and vice versa. Cortisol, when it is deficient or excessively high for prolonged periods of time, can slow down thyroid function. Folks with dysregulated cortisol and thyroid problems document this finding, showing that both high and low cortisol can impair thyroid function, although the relationship is not linear. Women who have too much or too little cortisol, plus an underperforming thyroid, get a double dose of fatigue, yet often neither condition is typically recognized in conventional medicine nor believed to be properly documented by existing biomarkers. When cortisol is just right, and in the normal range, the thyroid performs best and generates optimal levels of hormones. Reassess your symptoms six to twelve weeks after you’ve implemented the changes of Step 1. If you are still not feeling that your hormone issues are improved, add in Step 2 from both chapters. If you still are experiencing five or more symptoms from both chapters 4 and 9, see your doctor to consider further testing and a prescription for bioidentical hormones. Keep in mind that your thyroid medication requires adequate cortisol to work best: not too high and not too low. Dysregulated Cortisol and Dysregulated Sex Hormones (Estrogen and Progesterone) High cortisol is the single most common hormonal problem I see in my practice, and high cortisol with low estrogen and/or progesterone is another common combination. This varies by age: low progesterone coupled with high cortisol is the most common hormone combination that I see in women younger than thirty- five years of age. If you answered “yes” to three or more of the questions in chapter 1, Part A and/or Part B (the high and low cortisol questionnaires), together with three or more from Part C, Part D, and Part E, this is your hormone combo.

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It is assumed that barbiturate molecules penetrate the lipid bilayer membrane and increase the rigidity of its structural organization order dulcolax 5mg online treatment 4 autism. It is hypo- thetically possible that they can act 5mg dulcolax free shipping medicine emoji, as do a few other drugs of other classes such as gen- eral anesthetics, by changing the ability of the cell membrane to allow ion flow, influencing the secretion of neurotransmitters, and changing the conformation of enzymes. In other words, it is not improbable that they act according to receptor mecha- nisms, but by their own physical presence in the membrane. Clinically beneficial barbiturates are conventionally subdivided into four groups: (a) Long-acting barbiturates (6–8 h): mephobarbital, metharbital, and phenobarbital. Despite the fact that the present classifications are extremely convenient for practical med- ical personnel, it should be kept in mind that the duration of drug action—especially of the first three groups of compounds—depends on various factors besides the structure of the compounds, such as drug form, method of administration, pathology for which the drug is being used, general treatment time, etc. Barbiturates are used for brief periods of time for treating insomnia, since regular use of barbiturates (on average around 3 weeks) can lead to tolerance. Barbiturates are also used for controlling severe convulsive conditions and for treating various forms of epilepsy. They are used for pre- and post-operational sedation as well as in daytime sedation, for relieving patient anxiety, nervousness, and tension. Barbiturates are also used for treating catatonic and maniacal reactions, and as agents used in psychoanalysis (narcoanalysis and narcotherapy). Barbiturates are derivatives of barbituric acid and are synthesized by condensation of malonic acid derivatives with urea derivatives. In the literature, specific rules dealing with the cor- relation and activity in this series of compounds are described. As a rule, in order to exhibit central depressive action, barbiturates should contain two substituents on C5 of the hydrogenated pyrimidine ring. Moreover, drugs with bifurcated alkyl substituents have stronger hypnotic activity than substituents with normal carbon chains. Barbiturates with phenyl groups on C5 are weaker hypnotics than compounds with an aliphatic or alicyclic substituent; however, they have expressed antiepileptic and anticonvulsant action. N-methylation increases the lipid solubility of drugs and lessens the duration of drug action. It also can strengthen a drug’s antiepileptic properties, while methylation on both nitrogen atoms leads to convulsions. Substitution of an oxygen atom for a sulfur atom in the second position (thiobarbiturate), causes marked elevation of the distribution coeffi- cient in lipid–water mixtures in 5,5-disubstituted barbiturates. These compounds have more strength as hypnotics than their oxygenated analogs upon intravenous administra- tion; however, their low solubility in water and localization in fat storage make them unfit for oral use as hypnotics. They are primarily used as intravenous anesthetics (ultrashort- acting barbiturates). The first method consists of ethanolysis of benzyl cyanide in the presence of acid, giving phenylacetic acid ethyl ether, the methylene group of which undergoes acylation using the diethyloxalate, giving diethyl ester of phenyloxobutandioic acid (4. Alkylation of the obtained product using ethylbromide in the presence of sodium ethoxide leads to the formation of α-phenyl-α- ethylmalonic ester (4. It is widely used in treating epilepsy, chorea, and spastic paralysis, and is used as a component of a large number of combined drugs, valocordin and corvalol in particular. Talbutal is used as a sedative, soporific drug for the same indications as butabital. Soporific Agents α-ethylmalonic ester is carried out with 2-bromopentane (not 1-bromo-3-methylbutane) to give pentobarbital (4. They are similar in terms of action, and the difference lies in the fact that pentobarbital is shorter lasting and easier to tolerate. In particular, representatives of this series of benzodiazepines such as flurazepam, temazepam, and tri- azolam are used as hypnotics, while clonazepam is used as an anticonvulsant drug. Moreover, the most pharmacologically effective drugs presently used for treating sleep dis- turbances are flurazepam, temazepam, and triazolam.

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Transient protein C deficiency can be induced by treatment with warfarin dulcolax 5 mg overnight delivery medications gout, which promotes hypercoagulation through the action of the intrinsic pathway cheap dulcolax 5mg medicine youth lyrics. Thrombolytics Also called fibrinolytics, these agents lyse thrombi by catalyzing the formation of the endogenous fibrinolytic plasmin (a serine protease) from its precursor, plasminogen. Antiplatelet drugs inhibit this process, thus reducing the chances of thrombi formation. The major drugs are aspirin, ticlopidine, c1opidogrel, abciximab, eptifibatide, and tirofiban. Following a myocardial infarction, a patient is stabilized on warfarin, the dose being adjusted to give a prothrombin time of 22 seconds. Which of the following statements regarding potential drug interactions in this patient is accurate? Which of the following statements is true regarding the parenteral administration of streptokinase? A woman who has a mechanical heart valve and who is taking warfarin informs you that she hopes to get pregnant in the near future. What advice should she receive regarding her antithrombotic medication during the anticipated pregnancy? Warfarin binds extensively (98%) but weakly to plasma proteins and can be displaced by other drugs (e. Vitamin K restores levels of prothrombin and several other coagulation factors, but the action is slow (24 to 48 hours). The peak effect of heparin is not reached for several hours, and continued use over several days has no effect on thrombin levels. Its onset of anticoagulation activity is slow, and its impact on individual coagulation fac- tors depends on their half-lives. The intrinsic pathway continues to function for 2 to 3 days, causing a state of hypercoagulability and possible vascular thrombosis. Streptokinase is thrombolytic (or "fibrinolytic") because it activates plas- minogen, resulting in the increased formation of plasmin. All thrombolytics can cause bleeding, which may be counteracted to some extent by administration of antifibrinolysins, such as aminocaproic acid. Discontinuing warfarin is appropriate during pregnancy because it is a known teratogen that causes bone dysmorphogenesis. The patient will need continued protection against thrombus formation, and heparin (or a related low molecular weight compound) is usually advised, despite the fact that the drug will require parenteral administration and can cause thrombocytopenia. Mode of Action of Sulfonylureas Mechanisms: - Normally, K+ efflux in pancreatic ~ cells maintains hyperpolarization of membranes, and insulin is released only when depolarization occurs. The oral antidiabetic drugs are the sulfonylureas, metformin, acarbose, thiazolidinediones, and repaglinide. By blocking K+ channels in the pancreatic ~ cells, the sulfonylureas stimulate insulin release. Metformin enhances tissue sensitivity to insulin and inhibits liver gluconeogenesis. Acarbose inhibits intestinal a-glucosidase, thereby slowing glucose absorption and decreasing insulin demand.

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